Nicotine bitartrate dihydrate and nicotine polacrilex are both compounds used in nicotine replacement therapies (NRTs) to aid in smoking cessation, but they differ in their chemical composition and method of delivery.

Nicotine bitartrate dihydrate is a chemical compound consisting of nicotine combined with tartaric acid in a dihydrate form. It is typically used in pharmaceutical formulations for oral or transdermal administration, providing a controlled release of nicotine to help reduce withdrawal symptoms.

Nicotine polacrilex, on the other hand, is a resin complex of nicotine bound to polacrilex, a cation-exchange resin. It is commonly found in nicotine gum formulations used for oral administration. Nicotine polacrilex works by releasing nicotine slowly through the oral mucosa, helping to alleviate cravings and withdrawal symptoms associated with smoking cessation.

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